Clotrimazole is an antifungal with broad-spectrum and is structurally derived from imidazole and triazole. Fluocinolone acetonide is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations to provide relief of inflammatory dermatosis, dermatitis, psoriasis, hypertrophic tissues, keloid tissues and atopic dermatitis.. Ofloxacin is an antibiotic of fluoroquinolone family of medications useful for the treatment of a number of bacterial infections. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Therapeutic Indication
● Atopic Dermatitis
● Psoriasis of the scalp
● Dermatosis
● Fungal and bacterial infection of the dermal
● Candidiasis

Pharmacology

Mechanism of Action:
Ofloxacin: DNA replication requires DNA gyrase and topoisomerase IV. DNA gyrase allows the untwisting required to replicate one DNA double helix into two. Topoisomerase IV provides stability to the unwind DNA during replication. Ofloxacin inhibits these two and inhibit DNA replication thereby inhibits normal cell division.
Fluocinolone acetonide is a synthetic anti-inflammatory corticosteroid. It can be inferred that it acts by inhibiting the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, collagen deposition, and scar formation. Fluocinolone acetonide presents a high binding affinity for the glucocorticoid receptor. After binding the receptor, the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements in the promoter region of the target genes.
Clotrimazole inhibits fungus growth by inhibiting the division. It alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol and other sterols required for cell membrane production that eventually leads to cell death. It also inhibits the activity of enzymes within the cell.

Side Effects
● Rash
● Burning
● Stinging
● Swelling
● Irritation

How to Use
Apply this cream on infected portion after cleaning thoroughly.

Precaution
Do not apply on cuts and wounds.

Storage
Store below 25°C and do not freeze.

FOR EXTERNAL USE ONLY

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