It is given in cases where oral administration is not possible and also given to patients who had an allergic reaction to penicillin.
Indications
Indicated for the treatment of serious infections caused by anaerobic bacteria, including intra-abdominal infections, skin, and soft tissue infections
Uses
● Lower respiratory infections including pneumonia, empyema, and lung abscess when caused by anaerobes, Streptococcus pneumoniae, other streptococci (except Enterococcus faecalis), and Staphylococcus aureus.
● Skin and skin structure infections including cellulitis, abscesses, and wound infections when caused by Streptococcus pyogenes, Staphylococcus aureus and anaerobes
● Gynecological infections including endometritis, pelvic cellulitis, vaginal cuff infections, nongonococcal tubo-ovarian abscess, salpingitis, and pelvic inflammatory disease when caused by susceptible anaerobes or Chlamydia trachomatis
● Intra-abdominal infections including peritonitis and abdominal abscess when caused by susceptible anaerobes
● Septicemia caused by Staphylococcus aureus, streptococci (except Enterococcus faecalis), and susceptible anaerobes
● Bone and joint infections including osteomyelitis and septic arthritis when caused by sensitive strains of Staphylococcus aureus and anaerobes.
Mechanism of action
Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosome. It impedes both the assembly of the ribosome and the translation process. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
Mode of Administration
Clindamycin is given by qualified healthcare professionals in a hospital setting. It can be given directly into your vein (intravenous) or muscle (intramuscular), or as a drip (infusion). Your doctor will determine the dose you need each day and the frequency of injections based on your condition. It is important to complete the course of treatment to prevent re-infection.
Drug Interactions
● Erythromycin
● Rifampicin,
● Medicines that may be used during surgery
● Contraceptive pill
Side Effects
● stomach pain, cramps, or discomfort
● nausea and/or vomiting
● diarrhea
● Skin rash, irritation of the skin
● vaginal thrush - sore and itchy vagina and/or discharge
● low blood pressure (feeling of dizziness or light-headedness)
● joint pain and swelling
● pain, swelling, redness, or formation of an abscess at the site of the injection
Precautions & Warning
● If you are pregnant, thinking of getting pregnant, or are breastfeeding, ask your doctor or nurse for advice before they give you Clindamycin Injection
● Keep out of reach of the children
Dosage
Missed Dose:
A qualified healthcare professional administers Clindamycin in the hospital or clinical setting, so the likelihood of a missed dose is very low.
Overdosage:
Clindamycin is administered in the hospital or clinical setting by a qualified healthcare professional, therefore the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
Contraindications:
● Clindamycin Injection is contraindicated in patients who are hypersensitive to this drug or any component of this product
● If you have an allergy to Lincomycin
● Severe diarrhea associated with the use of antibiotics
● If you have a liver or kidney problem
● If you have a bowel disease and any gastrointestinal (stomach or gut) problems
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