Antagonist and Antihypertensive agent

Olmesartan Medoxomi Tablet

 
 
 
 
Olmesartan Medoxomi is an angiotensin II receptor antagonist used to treat high blood pressure. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Olmesartan blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.

Indications and Usage:
Olmesartan is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Mechanism of Action:
Olmesartan is a prodrug that works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle; it is therefore independent of angiotensin II synthesis pathways, unlike ACE inhibitors. By blocking the binding rather than the synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. As a result of this blockage, olmesartan reduces vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance.
atients in whom substances with a similar action (e.g. aspirin, or other NSAIDs), precipitate attacks of asthma, bronchospasm, acute rhinitis or urticaria or patients are hypersensitive to these drugs.
≈≈ Severe heart failure or severely impaired hepatic or renal organ function and during the last three months of pregnancy.

Storage :
Store at room temperature away from light and moisture.