Cranberry with D-Mannose combines cranberry extract (contains 1:15 ratio of Proanthocyanidine, polyphenols &anthocyanins) and D-mannose for dual support of urinary tract comfort. Most bladder infections – more than 90% – are caused by Escherichia coli (E. coli), a bacteria present in both the digestive tract and anal area.
One of the reasons women get so many urinary tract infections is due to anatomy. Not only is a woman's urethra close to the anal area, making it easy to come in contact with bacteria, but it is also close to her bladder, making it easy for the bacteria to gain entrance.
With our anatomy working against us, most women have had at least one or two bladder infections in their lifetime, even with the most meticulous hygiene. So, this combination is much more effective for UTI.
Cranberry extract and D-mannose are extremely beneficial for a faster and efficient resolution of UTIs.
Cranberry produces antimicrobial compounds such as proanthocyanidins in response to microbial invasion. Proanthocyanidins with A-type linkages from Cranberry are able to prevent growth, adhesion or bio film formation by a number of bacteria. Chemical changes caused by Cranberry extract create an energy barrier that keeps the bacteria from getting close to the urinary tract lining.

Urinary Tract Health:
Urinary Tract Infections (UTIs) are among the most common of all bacterial infections. Anyone of any age can have a UTI. However, young to middle-aged women who are sexually active are most often affected by UTIs. An infection occurs when microorganisms, usually bacteria from the digestive tract, cling to the opening of the urethra and begin to multiply. Most infections arise from one type of bacteria, Escherichia coli (E. coli), which normally live in the colon and causes about 80% of UTIs in adults. Symptoms of UTIs, both uncomfortable and debilitating, may include pain or burning with urination, the urge to urinate frequently while passing only small quantities of urine, tenderness or a feeling of heaviness in the lower abdomen, cloudy or foul-smelling urine, pain on one side of the back under the rib cage (flank pain), fever, chills, nausea and vomiting.
Most cases of UTIs are caused by the bacteria E. coli. This bacterium is normally present inside the digestive tract and on the skin surrounding the anus. In women, it is easier for the bacteria to travel to the urethra because the urethral opening is a lot closer to the anus than in men.
In order to cause an infection, bacteria must first adhere to the cells lining the urinary tract. They do these using hair-like fimbriae that protrude from their surfaces. The fimbriae attach to specific receptors on your cells.
D-mannose helps to prevent infections by interfering with the ability of the fimbriae to latch onto your cells.

Cranberry and D-Mannose as Urinary Tract Support:
Cranberry extract and D-mannose are extremely beneficial for a faster and efficient resolution of UTIs. Cranberry produces antimicrobial compounds such as proanthocyanidins in response to microbial invasion. Proanthocyanidins with A-type linkages from Cranberry are able to prevent growth, adhesion or bio film formation by a number of bacteria. Chemical changes caused by Cranberry extract create an energy barrier that keeps the bacteria from getting close to the urinary tract lining.
Cranberry extract provides urinary tract support without the unwanted sugar found in cranberry juice or juice cocktails, which can encourage the growth of unfriendly bacteria. It enhances the acidity of urine and maintains healthy urinary tract ecology. One study suggested the potential for cranberry juice to interact with lectin receptors and maintain a healthy bladder wall. D-Mannose, a simple sugar found in cranberries and other fruit, is included in this formula to provide additional concentrated support. One study examining the effect of d-mannose on epithelial cells suggested that it may play a role in supporting healthy genitourinary function by maintaining a healthy mucosal surface.
By preventing urinary tract infections, this supplement can also help reduce the need for antibiotics, unlike antibiotics which are useful for mainly acute, existing UTIs, it is suitable for prevention as a long-term use. Unlike antibiotics, Cranberry with Mannose avoids development resistance, secondary infections, side effect and is safe in pregnancy.

Indications :
The main functions of this combination are:
  • Supports your urinary tract health
  • Prevents bacteria from adhering to the walls of bladder
  • Effective against both antibiotic susceptible and resistant strains of bacteria
  • Maintains a healthy balance of flora
  • Supports optimal digestive health
  • Supports your immune system
  • Contributes to the maintenance of healthy intestinal flora
  • Helps fight off acute UTIs
  • Helps prevent UTI recurrence
  • Prevents bacteria from binding to the urinary tract
  • Safe and effective relief without the side-effects of Antibiotics
  • Synergistic combination
  • Potent anti-inflammatory and diuretic effect

About Composition:

Cranberry Extract:
Cranberries are a rich source of dietary phenolic bioactive including Proanthocyanidins, Polyphenols &Anthocyanins(Cranberry bioactives) have favorable effects on blood pressure, glucose metabolism, lipoprotein profiles, oxidative stress, inflammation, and endothelial function. This unique combination of cranberry produces synergistic health benefits.

Cranberry contains Proanthocyanidines:
Proanthocyanidins (PACs) are a class of biologically active flavonoids found throughout the plant kingdom, and are one of the most potent antioxidants in nature. PACs are the phytochemical responsible for many of the health benefits associated with cranberries. Science has shown that cranberries contain unique A-type PACs, seldom found elsewhere in nature, that provide bacterial anti-adhesive properties and help promote urinary tract, gastrointestinal, and oral health. PACs are the "power of the cranberry".
The PACs found in cranberries have a different structure than those found in other fruits and vegetables which are associated with their anti-adhesion properties. Cranberry PACs help prevent the adhesion of certain harmful bacteria, including E. coliassociated with urinary tract infections, onto cell walls.

Cranberry contains Polyphenols:
In the cranberry, specifically, polyphenols have been shown to reduce recurrent urinary tract infections, especially in women, help promote circulation and protect the body's cells and tissues from oxidative stress. The polyphenols found in cranberries have been shown to promote a healthy urinary tract and exert protective benefits for cardiovascular disease and other chronic conditions. Polyphenols provided by cranberries appear to be of a rather rare subtype. Whereas most berries and fruit contain a so-called B-type proanthocyanidin, cranberries are rich in A-type proanthocyanidin. The researchers believe that the anti-adhesive capacity of this polyphenol is the reason cranberries can help clear and protect against urinary tract infection (UTI).

Cranberry contains Anthocyanins:
The major anthocyanins in cranberry are galactosides and arabinosides of cyanidin and peonidin. Because of their superior antioxidant efficacy, cranberry anthocyanins may be expected to inhibit oxidative processes linked to tumorigenesis. Amounts of anthocyanins are remarkably high in cranberry, contributing to the color of the fruit and derived foodstuffs, as well as the potential effects on human health. American cranberry is one of the rare foods that comprise glycosides of the 6 aglycones of the anthocyanidin family: cyanidin, peonidin, malvidin, pelargonidin, delphinidin, and petunidin.

Cranberry Extract for an enhanced effect:
Cranberries have been used in the treatment of UTI for many years and are now regarded as a non-pharmaceutical approach for the treatment and prevention of simple UTI infections. Like D-Mannose, cranberries are effective in the treatment of the majority of UTI caused by E. coli.
Cranberries and cranberry extracts acidify the urine, which reduces bacterial growth. Furthermore, cranberries also contain certain tannins called proanthocyanidins that have been shown to reduce bacterial adherence to the urinary tract wall. This is a significant benefit in the treatment of UTIs as adherence is essential for infection.
Urinary tract infections affect the urinary system, including the bladder and urethra, caused by the development of bacteria. Women are more likely to develop a urinary infection than men, and these infections are often recurrent and painful.
Cranberry extract prevents the infection from reoccurring by stopping the bacteria from attaching to the cells that line the bladder.

D-Mannose is a monosaccharide, a simple sugar but unlike glucose it is absorbed eight times slower. Because it is hard for our bodies to absorb D-Mannose it passes straight to the blood stream, then through the kidneys into the bladder. Since it is not metabolized in the body like other sugars, it does not affect the blood sugar levels, and therefore is safe for the diabetic menu and does not cause weight gain.
D-mannose is a simple sugar that prevents adherence of certain bacterial strains to uro epithelial cells of the bladder. It prevents 90% or more of UTIs that are caused by the bacteria E.coli.
D-Mannose has antibacterial, antiviral and antifungal properties. It plays a key role in the formation of cytokines—the chemicals that make you feel achy when you're sick. Cytokines, in turn, stimulate the immune system to fight the parasitic invader.

Conditions Supported by D-Mannose
  • Urinary tract infections
  • Bladder health
  • Digestive health

How D-Mannose Works:
This simple sugar passes directly into the bloodstream and is absorbed more slowly than other sugars. As blood circulates through the kidneys, D-mannose molecules mix with urine and continue on to the bladder and urethra. All along the way, the D-mannose molecules support the urinary system's delicate ecological balance.
Additionally, D-mannose blocks the lectinsand can prevent them from breaching your intestinal wall.

The Role of D–Mannose in the prevention and treatment of UTI's:
Pathogenic bacteria's pili "grappling hooks" are specially designed to attach to a simple carbohydrate called D-Mannose, which is found on the cell surface receptors of the urinary tract host cells. When isolated urinary tract cells are bathed in D-Mannose, it acts as molecular "chaff." The bacteria bind to the D-Mannose in their environment instead of to the D-Mannose on the cells. This gums up their pili and prevents them from hooking onto urinary tract cells. Although D-mannose can eliminate UTIs as quickly as conventional antibiotic drugs, it is far safer because it does not kill E. coli or any "friendly" bacteria. Instead, it makes it impossible for E. coli bacteria to stick to the lining of the urinary tract, which allows the normal flow or urine to wash the bugs down the drain.

A synergistic combination:
D-Mannose is a simple carbohydrate that is found on cell walls. UTI causing bacteria recognize and latch on to D-mannose, which then allows them to infect the cell. Supplemental D-Mannose acts as a molecular decoy to prevent bacteria from attaching to and infecting bladder cells. Cranberry extract, on the other hand acts by acidifying the urine and also by reducing bacterial adhesion to the urinary tract wall. D-mannose and cranberry extract provide a natural, simple solution with no known side effects.

If a UTI treated with D-mannose does not show significant improvement within 24 hours (about 10% of cases), it is likely that the causative organism if not E. coli, and a visit to the doctor for a conventional vantibiotic drug is therefore necessary.

Side Effects:
  • If pregnant or lactating, consult your dietician before taking this product
  • Cranberry juice and D-mannose have been associated with gastrointestinal upset, nausea, vomiting, and diarrhea in some individuals
  • D-Mannose should not interfere with blood sugar regulation even for diabetics because so little is absorbed, though close monitoring is always advised. Consult your physician for more information

Store in a cool, dry & dark place. Protected from direct sunlight.